Discovering GLP-1: A Breakthrough in Weight Loss Solutions
The quest for a reliable and safe weight loss solution is an ongoing journey for many individuals. In this pursuit, a relatively recent contender, semaglutide, has continued to captivate attention more than a year after receiving approval from the U.S. Food and Drug Administration in 2021.
Originally developed as a diabetes medication administered via injections, semaglutide has emerged as a game-changer in the fight against obesity. It represents the first medication since Saxenda's approval in 2014 dedicated to managing chronic weight issues affecting a significant portion of the American population—70% of adults who are either overweight or obese. The evidence supporting the efficacy of semaglutide injections for weight loss underscores the importance of treating obesity as a chronic metabolic disorder, challenging the notion that willpower and lifestyle changes alone can effectively manage this condition. However, it's crucial to understand that semaglutide isn't a miracle cure, and it's not suitable for everyone.
"It is crucial to bear in mind that obesity is a multifaceted, chronic condition," emphasizes Dr. Vijaya Surampudi, a physician nutrition specialist and assistant director of the UCLA Weight Management Program (RFO). "There is no one-size-fits-all solution for obesity; it requires lifelong management."
So, what exactly is semaglutide, and how does it work?
Semaglutide falls under the category of glucagon-like peptide-1 receptor agonists (GLP-1 RAs), mimicking the GLP-1 hormone naturally released in response to food consumption. Among its roles, GLP-1 triggers the production of insulin, which helps lower blood sugar levels. Consequently, semaglutide has been employed in treating Type 2 diabetes for over 15 years.
However, GLP-1, when present in higher quantities, influences the brain's appetite-regulating mechanisms, promoting a sense of fullness and reducing hunger. When combined with a balanced diet and exercise regimen, semaglutide has demonstrated remarkable potential for significant weight loss, as well as a reduced risk of diabetes, cancer, and heart disease for individuals grappling with obesity or being overweight.
How does semaglutide fare for weight loss in non-diabetic individuals?
Several weight loss medications aim to curb appetite and foster weight reduction, but semaglutide takes this approach to a whole new level. In a preliminary study involving 2,000 obese adults, those who incorporated semaglutide into their diet and exercise program experienced striking outcomes. After 68 weeks, half of the participants using semaglutide shed 15% of their body weight, with nearly a third achieving a 20% reduction. In contrast, those who relied solely on lifestyle changes managed to lose only about 2.4% of their weight.
Dr. Surampudi offers some perspective: "The fundamentals of obesity management will always involve dietary and exercise modifications. However, having anti-obesity medications as an additional tool can make a significant difference, depending on the individual's clinical history."
What about the side effects of semaglutide injections?
Compared to the complications linked to obesity and excess weight, semaglutide's side effects are generally mild. Individuals using semaglutide for weight loss may encounter:
Dizziness
Fatigue
Gastrointestinal issues, such as diarrhea, constipation, and gas
Headache
Stomach-related problems, including nausea, vomiting, pain, or bloating
Among these, gastrointestinal issues are the most commonly reported side effect among those initiating semaglutide treatment. However, starting with a lower dosage and gradually increasing it can help mitigate these side effects.
Who should consider semaglutide for weight loss, and who should avoid it?
The FDA recommends Wegovy (the brand name for semaglutide) for weight loss if you meet any of the following criteria:
Have a body mass index (BMI) of 27kg/m2 or higher and at least one weight-related condition, such as high blood pressure, Type 2 diabetes, or high cholesterol.
Have a BMI of 30kg/m2 or higher.
Conversely, you should avoid semaglutide if you have:
A history of medullary thyroid cancer
A history of gallbladder disease
A history of pancreatitis
Multiple endocrine neoplasia syndrome type 2 (MEN2)
If you're contemplating GLP-1 medication for weight loss, call Activate Wellness Co. today for a FREE Consultation: 240-907-3739
The journey to a healthier weight starts with informed decisions and professional guidance.
Adapted from an article written by : Vijaya Surampudi, MD, MS
https://www.uclahealth.org/news/semaglutide-weight-loss-what-you-need-know